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  • Scientific Publications | Equistasi® Method

    Acute effects of high-frequency microfocal vibratory stimulation on the H reflex of the soleus muscle. A double-blind study in healthy subjects

    Alfonsi E., Paone P., Tassorelli C., De Icco R., Moglia A., Alvisi E., Marchetta L., Fresia M., Montini A., Calabrese M., Versiglia V., Sandrini G.

    1. This study in healthy subjects examined the effects of a system delivering focal microvibrations at high frequency (Equistasi®) on tonic vibration stimulus (TVS)-induced inhibition of the soleus muscle H reflex.

    2. Highfrequency microvibrations significantly increased the inhibitory effect of TVS on the H reflex for up to three minutes. Moreover, Equistasi® also significantly reduced alpha-motoneuron excitability, as indicated by the changes in the ratio between the maximumamplitude H reflex (Hmax reflex) and the maximumamplitude muscle response (Mmax response); this effect was due to reduction of the amplitude of the H reflex because the amplitude of muscle response remained unchanged. The present findings indicate that Equistasi® has a modulatory effect on proprioceptive reflex circuits. Therefore, Equistasi® might interfere with some mechanisms involved in both physiological and pathophysiological control of movement and of posture.

  • Scientific Publications | Equistasi® in the field of Parkinson's

    A wearable proprioceptive stabilizer (Equistasi®) for rehabilitation of postural instability in Parkinson’s disease: a phase II randomized double-blind, double-dummy, controlled study.

    Volpe D., Giantin MG., Fasano A.

    1. The aim of this pilot study is to test the feasibility and effectiveness of a balance training program in association with a wearable proprioceptive stabilizer (Equistasi®) that emits focal mechanical vibrations in patients with PD. Forty patients with PD were randomly divided in two groups wearing an active or inactive device. All the patients received a 2-month intensive program of balance training.

    2. Both groups improved at the end of the rehabilitation period and we did not find significant between-group differences in any of the principal posturographic measures with the exception of higher sway area and limit of stability on the instrumental functional reach test during visual deprivation at T1 in the Equistasi group. As for the secondary outcome, we found an overall better outcome in patients enrolled in the Equistasi group: 1) significant improvement at T1 on Berg Balance Scale (+45.0%, p =?.026), Activities-specific Balance Confidence (+83.7, p =?.004), Falls Efficacy Scale (-33.3%, p =?.026) and PDQ-39 (-48.8%, p =?.004); 2) sustained improvement at T2 in terms of UPDRS-III, Berg Balance Scales, Time Up and Go and PDQ-39; 3) significant and sustained reduction of the falls rate.
    A physiotherapy program for training balance in association with focal mechanical vibration exerted by Equistasi® medical device might be superior than rehabilitation alone in improving patients’ balance.
    P 044 – Effects of the Equistasi® neurological rehabilitation’s device on Parkinson’s disease patients’ gait

    F. Spolaor, A. Guiotto, D. Pavan, L. Arab Yaghoubi, A. Peppe, P. Paone, Z. Sawacha, D. Volpe

    1. Existing evidence indicates that NIFMV modulate neural transmission at different levels of CNS, contributing to motor control in deficient conditions. The availability of wearable devices for NIFMV, allowing easy, remote or home-based, continuative stimulations therefore should promote the use for symptomatic relief and supportive tool in neurorehabilitation of adult patients with ataxia or movement disorder.

    2. This study shows the use of Equistasi® as a support to improve locomotor abilities in patients with Parkinson’s Disease (PD) and also in adult patients with hereditary cerebellar ataxias.

    The neurorehabilitation device Equistasi® impacts positively on the gait of Parkinson’s disease subjects

    F. Spolaor, A. Guiotto, D. Pavan, L. Arab Yaghoubi, A. Peppe, P. Paone, Z. Sawacha, D. Volpe

    1. The aim of this study was to investigate the effects of Equistasi ®, a wearable device based on focal mechanical vibration proposed as an innovative rehabilitative strategy for the treatment of motor symptoms in people affected by PD.

    2. Gait disturbance is a key component of motor disability in PD patients, particularly, the gait cycle is influenced by rigidity, postural instability and camptocormic posture; in parkinsonians the stride and speed of the gait are decreased.

  • Scientific Publications | Equistasi® in the field of sports

    Acute effects of high-frequency microfocal vibratory stimulation on the H reflex of the soleus muscle. A double-blind study in healthy subjects.

    Alfonsi E., Paone P., Tassorelli C., De Icco R., Moglia A., Alvisi E., Marchetta L., Fresia M., Montini A., Calabrese M., Versiglia V., Sandrini G.

    1. 1. This study in healthy subjects examined the effects of a system delivering focal microvibrations at high frequency (Equistasi®) on tonic vibration stimulus (TVS)-induced inhibition of the soleus muscle H reflex.

    2. Highfrequency microvibrations significantly increased the inhibitory effect of TVS on the H reflex for up to three minutes. Moreover, Equistasi® also significantly reduced alpha-motoneuron excitability, as indicated by the changes in the ratio between the maximumamplitude H reflex (Hmax reflex) and the maximumamplitude muscle response (Mmax response); this effect was due to reduction of the amplitude of the H reflex because the amplitude of muscle response remained unchanged. The present findings indicate that Equistasi® has a modulatory effect on proprioceptive reflex circuits. Therefore, Equistasi® might interfere with some mechanisms involved in both physiological and pathophysiological control of movement and of posture.

  • Scientific Publications | Equistasi® in the field of multiple sclerosis

    The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study

    Spina E., Carotenuto A., Aceto MG., Cerillo I., Silvestre F., Arace F., Paone P., Orefice G., Iodice R.

    1. The aim of this study was to assess whether FV is effective on walking impairment in a cohort of MS patients.

    2. We performed a single-centre randomized, double-blind, sham-controlled study to investigate efficacy of FV vs sham vibration in 20 RR MS patients. Ten patients received treatment with the active device and ten patients sham treatment. Demographical, clinical and gait instrumental data analysis have been collected for each patient at baseline (T0), after treatment (T1) and after three weeks of wash out (T2). Our results suggest a beneficial effect of FV on walking impairment in MS patients suffering from spasticity and/or postural instability, which partially lasted until follow up.

  • Scientific Publications | Equistasi® in the field of cerebellar ataxia

    A wearable proprioceptive stabilizer for rehabilitation of limb and gait ataxia in hereditary cerebellar ataxias: a pilot open-labeled study

    Leonardi L., Aceto MG., Marcotulli C., Arcuria G., Serrao M., Pierelli F., Paone P., Filla A., Roca A., Casali C.

    1. The aim of this pilot study is to test the feasibility and effectiveness of a wearable proprioceptive stabilizer that emits focal mechanical vibrations in patients affected by hereditary cerebellar ataxias.

    2. Eleven adult patients with a confirmed genetic diagnosis of autosomal dominant spinocerebellar ataxia or Friedreich’s ataxia were asked to wear an active device for 3 weeks. Statistically significant improvements in SARA, 9HPT dominant hand, PATA test, 6MWT, cadence, length cycle, support right/cycle, support left/cycle, flight right/cycle, flight left/cycle, double support right/cycle, double support left/cycle, single support right/cycle, and single support left/cycle were observed between T0 and T1. This small open-labeled study shows preliminary evidence that focal mechanical vibration exerted by Equistasi® might improve limb and gait ataxia.

    Non-invasive Focal Mechanical Vibrations Delivered by Wearable Devices: An Open-Label Pilot Study in Childhood Ataxia

    Tommaso Schirinzi, Alberto Romano, Martina Favetta, Andrea Sancesario, Riccardo Burattini, Susanna Summa, Gessica Della Bella, Enrico Castelli, Enrico Bertini, Maurizio Petrarca, Gessica Vasco.

    1. The aim of this open label pilot study was to evaluate the feasibility, safety and effectiveness of NIFMV by WS in a cohort of 10 patients with childhood ataxia, a phenomenological category including different conditions still lacking of effective symptomatic therapies.

    2. Through the assessment of both clinical rating scales and spatio-temporal gait parameters via standardized gait analysis, we observed that a 4 weeks long treatment with WS Equistasi® was safe and provided significantly different effects in stride features of patients with slow/non-progressive cerebellar ataxia and Friedreich’s Ataxia.